Search
111 articles for “path discovery”
-
AI EdTech Synergy: From Chalkboards to Smartboards
Abstract: Beyond textbooks and classrooms, AI paints a future from adaptive tutors to immersive realities. AI is not just a tool sculpted by algorithms but an architect of a learning revolution where knowledge becomes truly boundless. The convergence of AI marks an era of revolution in learning, promising individualized learning pathways, optimized evaluative metrics, interactive virtual pedagogies, and enhanced accessibility. This convergence examines the emergent field of AI-powered educational innovation, shedding …
Published in Journal of Open Source Developments · Vol. 12, Issue 3, 2025 · pp. 18–25 Read article
-
Acute Toxicity and Histopathological Evaluation of Polyherbal Formulations of Annona Squamosa, Zingiber Officinalis and Triticum Aestivum in Wistar Rats
Abstract: The relationship between dose and its effects on the exposed organism is of high significance in toxic evaluation. The present study was aimed for the safety assessment of methanolic extract of Annona squamosa, Zingiber Officinalis and Triticum aestivum as polyherbal formulations at different ratios in albino Wistar rats. Sighting study was conducted in one female rat by administering 300 mg/kg body weight of polyherbal formulation through oral gavage. There were …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 6, Issue 3, 2019 · pp. 1–7 Read article
-
Next-Generation Biorepositories: Accelerating Infectious Disease Research and Vaccine Innovation
Abstract: Next-generation biorepositories have emerged as critical infrastructure for advancing infectious disease research and accelerating vaccine development. By integrating cellular, genomic, and clinical data within harmonized frameworks, these repositories overcome traditional limitations of fragmented datasets and limited interoperability. The evolution from conventional biobanks to digitally enabled, multi-omics platforms has enabled comprehensive analysis of pathogen–host interactions, facilitating the identification of novel vaccine targets and correlates of protection. The COVID-19 pandemic underscored the …
Published in International Journal of Vaccines · Vol. 3, Issue 2, 2026 Read article
-
An Introduction of Glycoside- “It’s Classification, Biogenesis, Identification, Extraction and Healthful Uses”
Abstract: A glycoside is a molecule within which a sugar is absolute to another functional group through a glycoside bond. Glycosides play various vital roles in living organisms. Several plants store chemicals within the kind of inactive glycosides. It may be activated as thanks to that sugar half broken off then its creating the chemical offered to be used. In common terms, an organic compound is any molecule within which a …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 2, Issue 3, 2015 · pp. 4–11 Read article
-
Inhibition of PI3K/Akt/mTOR Signaling Pathway by Vitis Vinifera Phytocompounds: A Promising Strategy for Supressing Colorectal Cancer Growth and Metastasis
Abstract: Objectives: Colorectal cancer was not typically identified a few decades ago. Today, with almost 900 000 fatalities each year, it is the fourth most dangerous cancer in the world. Colorectal cancer is responsible for about 10% of all cancer diagnoses annually and cancer-related deaths worldwide. It is the second most common type of cancer in women and the third most common type in men. Incidence and death are roughly 25% …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 1, Issue 2, 2023 · pp. 64–75 Read article
-
Underbalanced Drilling and Its Advancements: An Overview
Abstract: Ever increasing global energy demand associated with depletion of conventional hydrocarbon resources drives exploration and production (E&P) industry to invent advanced new technologies in frontier areas of drilling, production and reservoir engineering to enhance hydrocarbon production from unconventional resources or depleted reservoirs. Demand to produce from a low pressure marginal reservoir and the discoveries of naturally fractured reservoirs lead to the development of new drilling techniques like underbalanced drilling along …
Published in Journal of Petroleum Engineering & Technology · Vol. 4, Issue 2, 2014 · pp. 37–51 Read article
-
In Silico Molecular Docking of Indigofera tinctoria Phytocompounds to Target EGFR/ERK and FGFR/FGF Pathway Proteins Involved in Prostate Cancer
Abstract: Objective: Prostate cancer being the second major cause of cancer-related deaths in males, affects the small walnut-shaped gland below the bladder called the prostate gland. The epidermal growth factor protein (EGFR), cascade protein (ERK), and fibroblast growth factor proteins (FGFR and FGF) are involved in the different signaling pathways that lead to the formation of different products, that are responsible for the progression of cancer and thus can be considered …
Published in International Journal of Molecular Biotechnological Research · Vol. 1, Issue 1, 2023 · pp. 34–56 Read article
-
Gravitational Wave Astronomy (2015–2026): From Historic Discoveries to Quantum Detection Frontiers
Abstract: Since the landmark detection of GW150914 by the LIGO Scientific Collaboration in 2015, gravitational wave (GW) astronomy has transitioned from a theoretical frontier to a robust observational science. This breakthrough confirmed a major prediction of General Relativity and inaugurated an entirely new method for observing the universe. Over the past decade, continuous upgrades to ground-based interferometers such as LIGO, Virgo Collaboration, and KAGRA have dramatically improved detector sensitivity, enabling the …
Published in International Journal of Universe · Vol. 2, Issue 1, 2026 · pp. 1–5 Read article
-
2D-QSAR Studies on Unsaturated 4-Azasteroids as 5α-reductase Inhibitors
Abstract: Dihydrotestosterone (DHT) a major circulating male hormone is produced by NADPH dependent enzyme 5α-reductase (5 alpha R) and has been found to be causative agent in the development of pathological condition i.e. benign prostate hyperplasia (BPH). Thus inhibition of 5α-reductase enzyme represents a novel target in the treatment of BPH. Present study describes the relationship between the 5α-Reductase inhibitory activity for structurally related unsaturated 4-azasteroids derivatives and their physicochemical descriptors …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 26–37 Read article
-
Exploring Potential Phytochemicals for Myasthenia Gravis Treatment: A Molecular Docking and ADME Analysis Approach
Abstract: Objective: Muscle feebleness and exhaustion derived from a disruption in neuromuscular transference are hallmarks of the crippling autoimmune disease myasthenia gravis (MG). The drawbacks of the current MG therapy options are frequently partial efficacy and adverse effects. To investigate the potential of phytochemicals in MG control, in this work we integrated molecular docking with ADME (absorption, distribution, metabolism, and excretion) analysis using a computer method. We identified molecules exhibiting favorable …
Published in International Journal of Molecular Biotechnological Research · Vol. 2, Issue 2, 2024 · pp. 1–13 Read article
-
In Situ Investigation of Hemidesmus indicus Phytocompound Extracts as a Therapeutic Target for Acute Myeloid Leukemia
Abstract: Objective: Acute myeloid leukemia (AML) is an apoptotic condition in the hematopoietic system induced by the differentiation and maturation of stem cells into erythrocytes, and leukemic cell proliferation is suppressed as the PI3K-Akt-mTOR pathway is pharmacologically targeted with certain inhibitors. As a result, in silico molecular docking of compounds against AML receptors, CTMP, was used in computational research on Hemidesmus indicus to uncover therapeutic phytochemicals for AML. Thus, this study …
Published in Research and Reviews : Journal of Computational Biology · Vol. 13, Issue 1, 2024 · pp. 38–53 Read article