Volume 6, Issue 1 (2019)
Published
Table of contents
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A Review on Polymeric Nano-particles
Abstract: Conventional drugs have major demerits of poor biodistribution, decreased effectiveness and less targeting effect. Strategies like controlling drug delivery can potentially overcome these limitations by transporting drug to the place of action. The polymeric nanoparticles (PNPs) are prepared from biocompatible and biodegradable polymers in size between 1–1000 nm. PNPs are suitable carriers for drug delivery to specific target site; such an advantage improves the drug safety and lowers toxicity. In …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 1–7 Read article
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Formulation Development, Characterization and in-vitro Evaluation of Nano-Lipid Carriers of Ropinirole HCl for Persistent Parkinsonian Management
Abstract: According to a report of World Health Organization (WHO) 2014, Parkinson's Disease (PD) is the second-most neurodegenerative dysfunction of the central nervous system (CNS) of human being effecting 7–10 million people worldwide. It is primarily due to the death of dopamine-generating cells in the substantia-nigra of midbrain. It is symptomatized by tremor, rigidity, bradykinesia, dementia, depression and falls or emerges with the progression of the disease. Ropinirole HCl is a …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 14–23 Read article
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Microsphere: A Novel Drug Delivery System Approach
Abstract: Microspheres are the multiarticulate novel drug delivery dosage form, it contains the particle size range from 1 to 50 µ and characteristically spherical in shape with free flow property. It is widely known as “Microparticles”. Microspheres are prepared by covering the drug particles with polymeric solution (obtained in natural, semisynthetic or synthetic form) to achieve controlled release of drug, which produces prolonged action with reduced toxicity at the specified site …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 24–30 Read article
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Pharmacological Modeling of New Form of Anti-tumorigenic Medicines in Chemotherapy
Abstract: The existing methods of chemotherapeutic treatment do not permit to calculate the precise dose of medicine and the time of its action on the tumor that leads to unpredictability of result, and, therefore, to the ineffectiveness of the use of treatment itself. Furthermore, the damage of normal cells on chemotherapy becomes the reason for a whole series of complications, connected with side-effects action of chemotherapy. The paper presents the pharmacological …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 31–36 Read article
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Drug Master File—Electronic Submission through eCTD: An Overview
Abstract: A Drug Master File (DMF) is a supporting document for various applications such as Investigational New Drug Application (IND), New Drug Application (NDA), Abbreviated New Drug Application (ANDA), Biologic License Application (BLA), etc. Mainly product’s chemistry, manufacturing, and control (CMC) part is covered in the DMF. As per the current guidelines of US Food & Drug Administration (USFDA), all types of DMFs are mandatory to be submitted through Electronic Common …
Published in Trends in Drug Delivery · Vol. 6, Issue 1, 2019 · pp. 8–13 Read article