Research and Reviews : Journal of Computational Biology
Volume 14, Issue 2 (2025)
Table of contents
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Computational Investigation of Phytochemicals Targeting AKT1 for Major Depressive Disorder: A Molecular Docking and ADMET Study
Abstract: Major depressive disorder (MDD) is a prevalent neuropsychiatric condition affecting approximately 280 million individuals worldwide, with women exhibiting a 50% higher likelihood of diagnosis than men. Despite significant advancements in treatment, MDD remains a chronic and relapsing disorder, necessitating the exploration of novel therapeutic interventions. This study focuses on the AKT1 gene, a key player in neuropsychiatric disorders, and investigates its interactions with natural phytochemicals as potential alternatives to conventional …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Neurodevelopmental Effects of Cell Tower Radiation in Children: A Longitudinal Study
Abstract: This study investigates the impact of radiation exposure from cell phone towers on the neurodevelopmental outcomes of children aged 0–5 years. A prospective cohort approach was employed to assess key developmental parameters, including Gross Motor Skills, Fine Motor Skills, and sleep disorders. Given the increasing presence of wireless communication infrastructure, understanding its potential effects on early childhood development is crucial for public health.To analyze the collected data, advanced machine learning …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Remote Monitoring Sensor Systems and Applications in Health Informatics: Fostering Shell Programming
Abstract: The fascination of sensor systems has been promising for health informatics as their direct initiative for real-time information by observing its accuracy that was required at the time for data collection, monitoring and analysis to improve patient well-being and health system administering. By integrating these systems with wearable devices, biomedical sensors, and other IoT-enabled technologies, patients can experience continuous health tracking, early disease detection, and remote patient monitoring. For example, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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Repurposing Liv-52 For Primary Sclerosing Cholangitis: A Computational Docking And Pharmacokinetic Study To Evaluate Its Bile Flow-Regulating Potential
Abstract: Primary Sclerosing Cholangitis (PSC) is a long-term liver disease where the bile ducts become inflamed and scarred over time. This scarring can block the flow of bile, leading to liver damage and, eventually, liver failure. The etiology of PSC remains largely unknown, and current treatment options are limited, highlighting the need for novel therapeutic strategies. This study aims to repurpose Liv-52, a traditional herbal formulation known for its hepatoprotective properties, …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article
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A Python-Based Investigation of Clinical Data and Ultrasound Images for PCOS Diagnosis
Abstract: PCOS is a common endocrine disorder that impacts women in their reproductive years characterized by irregular menstrual cycles, hyperandrogenism, and polycystic ovaries. The full diagnostic plan is mainly a combination of a pelvic ultrasound besides blood tests of specific parameters that indicate the presence of PCOS. Since PCOS is a hard-to-diagnose widespread hormonal disorder, blood tests, symptoms, and other parameters with the help of a computer can form a new …
Published in Research and Reviews : Journal of Computational Biology · Vol. 14, Issue 2, 2025 Read article