Research & Reviews: A Journal of Bioinformatics
Volume 3, Issue 2 (2016)
Published
Table of contents
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A Review on Protein Structure Prediction
Abstract: Protein structure prediction is the inference of the three-dimensional structure of a protein from its amino acid sequence. The prediction of folding and secondary and tertiary structure from its primary structure. Structure prediction is fundamentally different from the inverse problem of protein design. Protein structure prediction is one of the most important goals pursued by bioinformatics and theoretical chemistry. It is highly important in medicine and biotechnology. Every two years, …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 3, Issue 2, 2016 · pp. 1–7 Read article
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Molecular Docking: A Powerful Approach for Structure based Drug Discovery
Abstract: Molecular Docking is a method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex. Knowledge of the preferred orientation in turn may be used to predict the strength of association or binding affinity between two molecules using, for example, scoring functions. The associations between biologically relevant molecules such as proteins, nucleic acids, carbohydrates, and lipids play a central …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 3, Issue 2, 2016 · pp. 15–19 Read article
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Molecular Dynamics Simulation of RND Efflux Pumps Involved in Multidrug Resistance
Abstract: The appearance of resistant strains of Gram-negative bacteria against antibiotics has compromised the efficiency of treatment. Multidrug resistance (MDR) is mainly due to the involvement of Resistance-nodulation division (RND) efflux pumps that actively pump out the drugs. For inhibition of the pump, it is essential to understand the structure as well as molecular basis of the process. Molecular dynamics (MD) simulation is employed to understand the conformational dynamics and functional …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 3, Issue 2, 2016 · pp. 20–24 Read article
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An Overview on Bioinformatics and its Application
Abstract: Bioinformatics has become an important part of many areas of biology. The term ‘Bioinformatics’ was coined by Paulien Hogeweg in 1979. In experimental molecular biology, bioinformatics techniques such as image and signal processing allow extraction of useful results from large amounts of raw data. In the field of genetics and genomics, it aids in sequencing and annotating genomes and their observed mutations. It plays a role in the text mining …
Published in Research & Reviews: A Journal of Bioinformatics · Vol. 3, Issue 2, 2016 · pp. 8–14 Read article