International Journal of Pathogens
Volume 2, Issue 2 (2025)
Table of contents
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Host Invasion to Immune Evasion: Emerging Concepts in Pathogen Virulence Strategies
Abstract: Pathogens have evolved a wide repertoire of virulence strategies that allow them to invade host tissues, establish infection, and circumvent immune responses. From the initial steps of adhesion and colonization to complex molecular mimicry, antigenic variation, and immunomodulation, pathogens display remarkable adaptability. While traditional research has emphasized host cell entry and toxin production, emerging evidence highlights subtler and more dynamic strategies such as manipulation of host signaling pathways, subversion of …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 Read article
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Epidemiology and transmission of infectious diseases study using Machine learning
Abstract: Infectious diseases remain a formidable global health challenge, characterized by rapid evolution and complex transmission dynamics that often outpace traditional epidemiological surveillance and response mechanisms. This study investigates the transformative potential of machine learning (ML) methodologies to enhance our understanding and prediction of infectious disease epidemiology and transmission. Leveraging diverse datasets—including clinical records, genomic sequences, environmental factors, social mobility data, and real-time digital footprints—we studies and presented various ML models …
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Epidemiology of Stomach Cancer in Northeastern States of India: Focusing on Nagaland and the Effectiveness of Screening Programs
Abstract: Stomach cancer represents a critical public health burden in northeastern India, with Nagaland exhibiting the highest age-standardized incidence rate in the country - nearly triple the national average. This elevated risk profile stems from multiple factors including traditional dietary practices (high consumption of smoked meats and fermented foods), widespread Helicobacter pylori infection (affecting approximately 70% of adults), prevalent tobacco/alcohol use, and limited healthcare infrastructure. Despite demonstrated success of endoscopic screening …
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A study on IoT and AI for Predictive Modeling and Control of Infectious Disease Transmission
Abstract: Background: The global response to novel and recurring infectious diseases is frequently hindered by surveillance systems that are slow, siloed, and reactive. Traditional epidemiology relies on retrospective analysis of clinical reports, often missing the critical early phase of autocatalytic spread. The urgency of modern public health necessitates a shift toward real-time, predictive intelligence. Methods: This study investigates the development and deployment of a synergistic paradigm integrating the Internet of Things …
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Understanding Airborne Pathogens: Pathways, Risks, and Control Strategies
Abstract: Airborne transmission is the transfer of germs through the air, mostly by respiratory droplets and aerosols that come out when you cough, sneeze, talk, or breathe. These particles can stay in the air for a long time and move a long way, especially in small or poorly ventilated places. Mycobacterium tuberculosis, measles virus, varicella-zoster virus (chickenpox), influenza virus, and more recently, SARS-CoV-2 are all infections that can be spread through …
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Host-Pathogen Coevolution: Implications for Immune Evasion and Pathogen Fitness
Abstract: The interaction between hosts and pathogens represents a continuous evolutionary struggle, shaping both microbial virulence and host immunity. Pathogens employ diverse strategies to evade immune surveillance, ranging from antigenic variation and molecular mimicry to hijacking of host immune checkpoints. Simultaneously, hosts refine innate and adaptive immune mechanisms to counteract infection and limit damage. This reciprocal adaptation, known as host–pathogen coevolution, influences pathogen persistence, transmission, and fitness, while also sculpting immune …
Published in International Journal of Pathogens · Vol. 2, Issue 2, 2025 · pp. 6–10 Read article