International Journal of Cell Biology and Cellular Functions
Volume 4, Issue 2 (2026)
Table of contents
-
Mass Spectrometry–Based Phosphoproteomic Markers to Predict Kinase Inhibitor Response in Solid Tumors
Abstract: Mass spectrometry-based phosphoproteomics has emerged as a powerful tool for predicting kinase inhibitor responses in solid tumors, offering direct functional insights into signaling pathways that surpass traditional genomic profiling by capturing dynamic kinase activities and adaptive resistance mechanisms. Technological breakthroughs, including data- independent acquisition (DIA), trapped ion mobility spectrometry (timsTOF), and efficient enrichment methods like TiO2 or IMAC, now enable comprehensive profiling of over 40,000 phosphorylation sites from limited clinical …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
-
Unveiling Therapeutic Targets in COPD: A Synergistic Approach Using Network Pharmacology and Molecular Docking
Abstract: COPD is a chronic lung disease that affects a large number of people worldwide and is a cause of death. Despite existing medications, effective therapies with fewer side effects is still needed. The use of herbal medicine, especially Zataria multiflora, has proven to be useful because of its antioxidant and anti-inflammatory properties. The mechanisms involved in COPD with it, however, are still not fully understood. In this research, network pharmacology …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
-
The Cellular Architecture of Feed Efficiency: Can Single-Cell Multi-Omics, Spatial Metabolomics, and Nutrient-Flux Mapping Reveal Hidden Metabolic Specialization across Intestinal, Hepatic, and Skeletal-Muscle Cell Populations in Poultry?
Abstract: Feed efficiency in poultry emerges from complex interactions among nutrient absorption, metabolic transformation, cellular energy expenditure, and productive tissue accretion. However, conventional whole-organ and bulk-tissue approaches inadequately capture the cellular heterogeneity underlying nutrient utilization and metabolic efficiency. This review proposes a cell-resolved framework integrating single-cell multi-omics, spatial metabolomics, and stable-isotope nutrient-flux mapping to elucidate hidden metabolic specialization across intestinal, hepatic, and skeletal-muscle cell populations. Particular emphasis is placed on intestinal …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
-
The Redox Rheostat: A Review on Targeting the Oxidative Stress-to- Cell Death Continuum for Therapeutic Gain
Abstract: For a long time, oxidative stress was cast as a plain villain, something to be pushed down with antioxidants wherever it appeared. That view has changed. Reactive oxygen species (ROS) do real work in the cell. At low concentrations, molecules such as hydrogen peroxide act as signals. As stress increases, cells activate protective mechanisms to keep themselves safe. However, if the stress becomes too strong or lasts too long, these …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 Read article
-
Sequence analysis, DNA Methylation and Molecular therapy of Oral cancer caused by Human Papilloma Virus
Abstract: DNA methylations with oral cancer are been associated with high-risk Human Papillomavirus (HPV) and Epstein-Barr Virus (EBV) onco-proteins interactions may cooperate to increase disease severity. The work focused on human papillomavirus strain 16, a high-risk, sexually transmitted responsible for 95% of all cervical cancers and a large portion of oropharyngeal cancers. The prediction of genes from has shown seven genes from HPV16 strain. Based on gene identification studies, Human papilloma …
Published in International Journal of Cell Biology and Cellular Functions · Vol. 4, Issue 2, 2026 · pp. 1–9 Read article