STM Journals Peer-reviewed research from Consortium e-Learning Network

2 publications

  • Published Subscription

    In Silico Study on Estrogens Receptor Modulators as Anti-cancer Agents

    By Azmin M Mogal, Malleshappa N Noolvi, Uttam A More

    Abstract: The clinical selective estrogen receptor modulator tamoxifen is most commonly used drug for the treatment of estrogen positive breast cancer and has been preventing lives worldwide. The pioneering drug; tamoxifen used in both treatment and prevention of estrogen positive breast cancer and also addressing new research for selective estrogen receptor modulators (SERMs). Based on these for current study 20 tamoxifen derivatives has been designed for in silico study. For the …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 41–54 Read article

  • Published Subscription

    3D-QSAR Studies on Protein Phosphatase 2A Inhibitors as Anti-cancer Agents

    By Zofina Patel, M. N Noolvi, Uttam A More

    Abstract: The tremendous efforts by researcher indicates that cantharidin, nor cantharidin and their analogues shows anti-cancer activity due to their inhibition of cancer cell lines such as HT29, SW480, MCF-7, A2780, H460, A431, DU145 and L1210. The anti-cancer activities of cantharidin, nor cantharidin and their analogues involve the inhibition of serine/threonine protein phosphatises (PPs) activity. In this study, three-dimensional quantitative structure activity relationship (3D-QSAR) like comparative molecular field analysis (CoMFA), and …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 1–19 Read article

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