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• Published Subscription 4 Mar 2019

  QSAR Studies of 3-(4-(3-(Substitutedphenyl) Acryloyl) Phenyl)-2-Substituted phenyl/Phenylthiazolidin-4-ones for Anticancer Activity

  By Ruchika Goyal, Ashwani Kumar, Sunil Kumar, Sandeep Jain, Parvin Kumar

  Abstract: Both, Chalcone and 4-thiazolidinone, are therapeutically significant organic moieties with anticancer activities. QSAR (Quantitative structure–activity relationship) studies of ten synthesized chalcone-thiazolidinone hybrids have been described for anticancer activity against three cancer cell lines: A-549 (Human lung adenocarcinoma), U-87 MG (Human glioblastoma cancer cells) and COLO-205 (Human colon cancer cells). The developed linear QSAR models have significant statistical quality showing good fitting ability and robustness. The Q2 and R2 values of …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 3, Issue 3, 2016 · pp. 16–22 Read article →