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Lithium Induces Lower Specific Activity and Expression of Acetylcholinesterase in Old Aged Rats Brain and Liver for the Regulation of Acetyl Choline Cellular SignalingBy Prabha M, Smitha T Patil, Suneetha P, Lokesh K N, Santh Kumar S
Abstract: Acetylcholinesterase (AChE) acts on acetylcholine (ACh) to terminate its actions on the synaptic cleft by cleaving Ach to choline and acetate. This directly correlates with memory dysfunction and loss of cognitive functions in Alzheimer’s disease (AD) patients which was a continuous decline of the cholinergic neurotransmission in cortical and other regions of human brain. Specific activity and expression for AChEwere determined in LiCl2 treated young and old male wistar rat's …
Published in Research and Reviews: A Journal of Neuroscience · Vol. 8, Issue 2, 2018 · pp. 1–12 Read article →