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Morinda citrifolia Leaf Induced Leukemia Cells Apoptosis and Produced Synergistic Effects with ZerumboneBy Negin Ahmadi, Heshu Sulaiman Rahman, Rozita Rosli, Tengku Azmi Tengku Ibrahim, Swee Keong Yeap, Suhaila Mohamed
Abstract: Leukemia is the most common cancer among children and the 7th most common cancer worldwide. The vegetable Morinda citrifolia leaves was investigated and compared with Zerumbone (a known anti-leukemia compound) separately and in combination, for their apoptotic effects on murine myelomonocytic leukaemia cell line (WEHI-3B). Zerumbone, a sesquiterpene from Zingiber zerumbet was anti-cancer via suppressing free radical generation, inflammation, cancer cell proliferation, metastasis, anti-apoptosis, NF-κβ, Iκβα kinase activation and invasion. …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 3, 2016 · pp. 24–32 Read article →