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2 publications

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    Synthesis and Anti-Bacterial Activity Profile of Cyclized Diazonium Compounds

    By Priti Jain, L. Naga Rajiv, Hemant R. Jadhav

    Abstract: Synthesis of cyclised diazonium compounds and their in vitro activity against various microorganisms is described. Several primary aromatic amines were diazotised and the resulting diazotised compounds were coupled with active methylene compounds to give hydrazono derivatives. These were cyclized with hydrazine hydrate, phenyl hydrazine, urea and o-phenylene diamine to give pyrazolin-5-one, substituted pyrazolin-5-ones, pyrimidin-di-ones and benzodiazepinone derivatives, respectively. Some hydrazine derivatives were also produced by reduction of diazo compounds with …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 1, Issue 1, 2014 · pp. 4–12 Read article

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    HDAC and HDAC Inhibitors: Implication in Different Pathological Ailments

    By Priti Jain

    Abstract: Histone deacetylases (HDAC) and its inhibitors have been found implicated in various diseased conditions. HDACs regulate the histone tail, chromatin conformation, protein-DNA interaction, and even transcription. They have also been found to regulate the post translational modifications through deacetylation of proteins, and hence are involved in many pathophysiological conditions. Till date, USFDA has approved vorinostat, romidepsin, panobinostat, and belinostat as HDAC inhibitors for the treatment of cancer. Considering their wide …

    Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 5, Issue 3, 2018 · pp. 35–40 Read article

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