1 publication

• Published Subscription 17 Jun 2021

  A Review on Targeted Protein Degradation and Its Novel Therapeutic Approaches

  By Nilesh s Pendbhaje, Ashwini A. Jamdhade, Shain M. Pathan, Rupali V. Nirmal

  Abstract: A new concept of drug development is drug-induced degradation of a target protein. Protein degradation is one of the cell's methods for permanently inactivating proteins. The Ubiquitin-Proteasome System (UPS) and autophagy are two main intracellular protein degradation pathways in eukaryotes. Autophagy has been shown to be induced by inhibiting proteasomal activities, suggesting a coordinated and complementary relationship between these two mechanisms. However, little is known about autophagy's function in UPS …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 8, Issue 1, 2023 · pp. 12–23 Read article →