4 publications
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Assessment of the effectiveness of PMTCT (Prevention of Mother to Child Transmission) to Children Born from HIV-1 positive MothersBy Nega Berhane, Fantahun Mekonnen
Abstract: Mother-to child transmission (MTCT) of HIV is one of the biggest challenges of the HIV/AIDS pandemic especially in resource constrained settings. Africa has the highest burden of the disease accounting for about 90% of pediatric HIV infections. Approximately 370,000 children became infected with HIV globally; most of these infections occurred through mother-to-child transmission. PMTCT (prevention of mother to child transmission) service reduces the risk of this transmission. In the absence …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 6, Issue 1, 2016 · pp. 9–16 Read article →
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Impact of PPAR-γ2 pro12Ala Gene Polymorphism and Susceptibility of Type 2 Diabetes Mellitus in Patients Visiting Gondar University Teaching HospitalBy Nega Berhane
Abstract: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that can occur through mechanisms such as; impaired insulin secretion, insulin resistance in peripheral tissues and increased glucose output by liver. Type 2 diabetes clearly represents a multifactorial disease, and several findings indicate that multiple genetic and environmental factors are important contributing factor involved in the pathogenesis of this disease. Recently great emphasis has been given to genetical factors to combat …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 2, 2015 · pp. 21–28 Read article →
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Frequency and Effect of CCR5 Alleles on HIV-1 Disease Progression among Untreated Seropositive Individuals Visiting Gondar University Teaching HospitalBy Nega Berhane, Eyayaw Assefa
Abstract: Abstract:The natural history of HIV-1 infection varies considerably from one individual to another, with some individuals progressing to AIDS rapidly after primary infection, while others remain clinically asymptomatic with no evidence of immune dysfunction. Recent studies have shown that reasons for progression and non-progression are multi-factorial and may involve genetic, virological and immunological factors that influence HIV disease progression in various ways. Chemokine receptors act as important co-receptors mediating the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 5, Issue 1, 2015 · pp. 8–13 Read article →
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Existence of Integron I and II Genes from Clinical Isolate Staphylococcus aureus and Their Role in Drug ResistanceBy Nega Berhane, Wagaw Sendeku
Abstract: An integron is a gene capture and dissemination system. They have been identified on both genomic and mobile genetic elements which often contain one or more genes that encode antibiotic resistance. They are commonly associated with bacterial genera in the family of Enterobacteriaceae. Currently, there have been recent reports showing the presence of integrons in Staphylococcus species. The aim of the present study was to assess the existanxe of Class …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 4, Issue 3, 2014 · pp. 18–24 Read article →