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• Published Subscription 4 Mar 2019

  2D-QSAR Studies on Unsaturated 4-Azasteroids as 5α-reductase Inhibitors

  By Neelima Dhingra, Priyanka Rana, Richa Dhingra, Monika .

  Abstract: Dihydrotestosterone (DHT) a major circulating male hormone is produced by NADPH dependent enzyme 5α-reductase (5 alpha R) and has been found to be causative agent in the development of pathological condition i.e. benign prostate hyperplasia (BPH). Thus inhibition of 5α-reductase enzyme represents a novel target in the treatment of BPH. Present study describes the relationship between the 5α-Reductase inhibitory activity for structurally related unsaturated 4-azasteroids derivatives and their physicochemical descriptors …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 4, Issue 1, 2017 · pp. 26–37 Read article →