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Drug-likeness and 3D-QSAR Analysis of 1,2,3-triazoles as Novel Potent HIV-1 Vif Inhibitors: An approach in the development of Leads in the Treatment of HIV InfectionBy Olalekan Ayodele AGEDE, Louis Okeibunor Odeigah, Maryam Abimbola Jimoh, George Oche Ambrose, Olufunke Esan Olorundare
Abstract: AbstractThe human immunodeficiency virus type 1 (HIV-1) Vif protein is one of various primate lentiviral accessory proteins that act as a virulence factor to advance viral duplication and persistence. 3D quantitative structure-activity relationship (QSAR) modeling of thirty-six (36) newly discovered 1,2,3-triazole analogs as potent novel inhibitors of HIV-1 Vif to predict their biological activity (pIC50), to try to improve/optimize it using some numerical data of HIV-1 Vif inhibitors based on …
Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 9, Issue 3, 2022 · pp. 23–37 Read article →