1 publication

• Published Subscription Case Report 25 Nov 2025

  Extra Philadelphia in CML Due to Isodicentric 22: A Case Report

  By Amudha S., Sanjukta S. Rao, Sweta Srivastava, Raina M. P., Mary Margaret A.

  Abstract: Introduction: Chronic Myelogenous Leukemia is a malignancy that affects the hematopoietic stems cells (HSC) of the bone marrow, leading to the rapid and continual proliferation of granulocytes and precursor blast cells. This is caused due to a reciprocal translocation that occurs between chromosomes 9 and 22, leading to the formation of derivative 22 also called as Philadelphia (Ph) chromosome. The Ph chromosome then encodes a fusion oncoprotein that functions as …

  Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 14, Issue 3, 2025 · pp. 18–22 Read article →