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An Experimental Pathological Study on the Prophylactic Effect of N-acetylcysteine on Alopecia from Anti-cancer DrugsBy Kwang-U Jon, Chol-Su Kim, Chol-Jun Ho
Abstract: Prevention of alopecia from anti-cancer drug, Cyclophosphamide, is important for improving quality of life in patients with cancer. Empirically, when Cyclophosphamide (150 mg/kg) infused to rats subcutaneously and intraperitoneally, severe alopecia developed in rats infused intraperitoneally. Moreover, rats infused both of N-acetylcysteine and Cyclophosphamide showed less skin vasculature and scaring of hair follicle, larger caliber of hair follicle and hair, thicker medullary and cortical layers and epimysium, and denser hair …
Published in Research and Reviews: A Journal of Medicine · Vol. 13, Issue 1, 2023 · pp. 21–27 Read article →