2 publications

• Published Subscription Review Article 2 May 2026

  Formulation Challenges in Long-acting Injectable Small Molecules: Emerging Strategies and Perspectives

  By Tejaram Choudhary, Firoz Ahmed, Tanya Sharma, Kamalesh Mistry

  Abstract: Long-acting injectable (LAI) formulations represent a transformative approach in pharmacotherapy, particularly for conditions demanding sustained drug exposure over weeks to months. Although biologics have dominated this space historically, the adaptation of LAI technology to small molecules presents a distinct and complex set of challenges rooted in physicochemical properties, manufacturing scalability, and regulatory expectations. This review systematically addresses the principal formulation barriers encountered in developing LAI small-molecule products, including aqueous solubility …

  Published in Research & Reviews: A Journal of Drug Design & Discovery · Vol. 13, Issue 2, 2026 Read article →

• Published Subscription Review Article 29 Sep 2025

  Gene Therapy 2.0: Harnessing Cutting-Edge Technologies for Precision Medicine

  By Gaurav Kumar Mahto, Tanya Sharma, Shubam Singh, Kamalesh Mistry, Md. Aftab Alam, Neha Nahid

  Abstract: Somatic gene therapy has become the standard form of gene therapy; this creates the Gene Therapy 2.0 era. This new and distinct time consists in the new-generation genome-editing tools and markers, more efficient systems for gene delivery, and personalized medicine approaches that raise the efficacy and safety of the treatment. Base and prime editing are two types of CRISPR-based gene editing tools have provided high precision and reduced off-target effects …

  Published in International Journal of Genetic Modifications and Recombinations · Vol. 3, Issue 2, 2025 Read article →