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Inhibition of Replication of Adenovirus by 6-diazo-5-oxo-L-norleucine (DON)By G. Goldstein, J. L. Harden
Abstract: Normal 0 false false false EN-US X-NONE X-NONE The antibiotic known as 6-diazo-5-oxo-L-norleucine (DON) inhibits the growth of several types of Gram-positive and Gram-negative bacteria. DON has also been demonstrated to inhibit the replication of poliovirus, respiratory syncytial virus, mumps, and herpes simplex virus in cultured eukaryotic cells. DON is an analogue of glutamine and inhibits the synthesis of glycoproteins and purine nucleotides in cells that are treated with the …
Published in Research and Reviews: A Journal of Microbiology and Virology · Vol. 6, Issue 3, 2016 · pp. 31–37 Read article →