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The Specificity of Purine Derivatives towards Xanthine Oxidase Enzyme and the Factors Affecting the Enzyme Catalyzed ReactionBy Gebremeskel Gereziher, Gidey Gebremeskel, Abebe Berhane
Abstract: Xanthine oxidase (XO) is a molybdenum-containing enzyme catalyzing the hydroxylation of a sp2-hybridized carbon in a broad range of aromatic heterocycles and aldehydes. Further, it is a key enzyme in the last two steps of purine metabolism. Thus, the need for an understanding and developing unified reaction mechanism to minimize the amount of accumulated uric acid inside human body has led us to the present detailed study of the reaction …
Published in Research and Reviews : A Journal of Life Sciences · Vol. 6, Issue 2, 2016 · pp. 28–44 Read article →