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• Published Subscription 12 Apr 2019

  Inhibition of MDA-MB-231 Breast Cancer Cell Proliferation by Simple Diphenyl Chalcone and Its Chlorinated Derivatives

  By Vitus A. Apalangya, Thomas Bakupog, Charmaine Tutson, Sebastian Sefadzi, Bernadette Early, Roberta M. Troy, Michael L. Curry, Pamela M. L. Robinson, Nichole L. Powell, Albert E. Russell

  Abstract: The pharmacological activities of chalcones and their derivatives are well documented. Chalcones are an important class of natural products that occur in edible plants such as spices, tea, fruits and other vegetables. In vitro studies have shown that chalcones inhibit proliferation of breast cancer cells by inducing apoptosis and blocking cell cycle progression. Substituent effects, namely, adding electron-withdrawing substituents to the chalcone structural motif, and the extents to which those …

  Published in Research and Reviews: Journal of Oncology and Hematology · Vol. 1, Issue 2, 2012 · pp. 7–12 Read article →